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Targeted clear glioma stem cells in the treatment of glioblastoma prospects

Expression of surface molecules in GSCs may be the ideal treatment of glioblastoma. The goal of these molecules are: CD133 (prominin-1), CD15, L1CAM, A2B5. Although CD133 has been widely used as a marker of GSCs but is normal neural stem cells also express CD133, limit its application. These molecules, in order to nerve cells best adhesion molecule L1CAM application prospects, it is expressed in the GSCs, play a key role on the the GSCs retention, survival and function. The L1CAM mediated extracellular and intracellular signal transduction, regulation of cell adhesion, migration, survival, growth, and tumor cells cellular invasion. Compared to glioblastoma tumor cells and normal neural progenitor cells the Cellular, L1CAM in GSCs high expression. Specific shRNA knockdown the L1CAM stem cells can interfere with in vitro form a ball of cells, and GSCs growth, for glioma stem cells L1CAM treatment can significantly inhibit intracranial Dutch GBM transplanted mice, tumor growth and prolong the life of tumor-bearing mice.

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